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Briefing Aug 11, 2020 03:12 pm EqualOcean

JW Therapeutics Studys on Adoptive T-cell Therapy with Lyell Immunopharma

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Aug 23, 2020 08:23 am ·

AI Is Transforming China's Healthcare Industry

► AI healthcare is an inevitable trend across the global, especially in the emerging market. ► Chinese AI healthcare companies are getting more mature, forming the industry landscape. Artificial intelligence, as a fundamental technology, can help power almost any industry. As one of the tier-one countries with the most AI hubs, China is experiencing a national digitalization across many sectors and across multiples disciplines. At the mid-stage of its digital reshaping, the healthcare industry is lit with a limelight that no market watcher can miss. Generally, smart technology helps the healthcare industry grow faster on innovation, and helps it grow smarter in various healthcare services. So far, AI healthcare in China includes ten areas, including drug development, auxiliary diagnostics, auxiliary treatment, health management, rehabilitation, online consultations, health wearables, hospital management, precision medicines and biotechnology research. An inevitable trend: Global and domestic Undoubtedly, the concept of healthcare and AI is exciting to investors. The capital resources can never be too much for players in this area. On a global scale, the healthcare AI funding was up 14% on a QoQ-based CAGR. In China, the funding activities have calmed down to a healthy status since the peak time in 2018, with a total investment amount of CNY 7.9 billion, occurring in 66 deals. Compared to the continuously dynamic global investment environment, China's capital market for healthcare AI seems to have cooled down since last year. The average investment amount per deal is CNY 61.4 million, CNY 181.2 million and CNY 147 million from 2017 to 2019. The first two quarters in 2020 saw 26 transactions completed at a total of CNY 1.8 billion, with an average deal amount of CNY 69 million. There are 129 Chinese AI healthcare companies in 2020, excluding those in targeted genetic research. Among them, 55 firms are in medical imaging, representing 42.6% of the total AI healthcare players. Most of the AI medical applications are based in triple-A hospitals, but they show an accelerated expansion trend. Exploiting various healthcare demand Undoubtedly, AI technology can be leveraged in far more healthcare areas. Medical imaging is just a starter. But how far can AI go down the healthcare path? To have a rough idea about the potential, we can have a general look at the fundamental technology. The AI in China can be dissected into six perspectives: computer vision, machine learning, natural language processing, data mining, speech conversion and speech interaction. As the underpinning technology, each angle of AI technology mentioned can vitalize niche healthcare segments on a technical level. Medical imaging and new drug discovery are two heated applications integrated with high-end AI. Besides, from a broader perspective, AI technology helps redistribute medical resources in an innovative way. On the one hand, it makes traditional medical facilities run smarter, faster and more effectively. The smart hospitals project has already been promoted in large-scale Chinese cities, following up on the great demand for electronic records, cloud records, data sharing, and online consultation. On the other hand, cloud technology connects doctors from end to end, making the medical expertise and knowledge more equal across regions. It is a well-known fact that China has a very unbalanced distribution of medical resources – almost 80% of medical resources are aggregated in 20% of hospitals. In contrast, grassroots clinics and hospitals in remote and lower-tier cities significantly lack high-quality supplies. Medical imaging for real-time surgeries makes it so that patients from everywhere consult prestigious expert doctors. Last but not least, one noteworthy fact is the fusion of multi-technologies in a stand-alone medical scenario. It implies that the medical demand for AI technology has been better understood and recognized. These medical demands are not a monolithic request but multi-faceted and technical-solution-demanding questions. The landscape of five primary healthcare segments Many AI healthcare companies have been trying out the market. The segment of medical imaging by far has grown to a heated red sea while other industries are experiencing the infant or booming stage. The AI technology has been used in these ten medical areas: drug development, auxiliary diagnostics, auxiliary treatment, health management, rehabilitation, online consultations, health wearables, hospital management, precision medicines and biotechnology research. However, from an industry perspective, we pick out some example companies in five primary healthcare segments. The AI healthcare is not a new concept anymore. As more companies in this field are eyeing the consumer market, the industry is starting to enter a mature phase. Meanwhile, some online healthcare companies – JD Health, Ping An Good Doctor and Ali Health – have been injecting AI technology into their consumer-oriented services.

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Jul 9, 2020 07:40 pm · Harbour Biomed

Anti-cancer Drug Maker Harbour Biomed Receives USD 102.8 M in Series C

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Jul 7, 2020 11:10 pm · https://mp.weixin.qq.com/s/kg8ECgzgWr1BZczDuNcyoA

Obio Technology Receives CNY 200 Million in Pre-Series C

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Jun 14, 2020 11:00 am ·

Clinical CRO Tigermed: The ‘Small and Beautiful’

► In China’s CRO industry, Tigermed is considered as the flagship player with a focus in clinical stages. ► The R&D efficiency is important to all these research-driven companies. There are advantages both from coming synergies due to wide coverage and from precision in a focus. When the growth rate of global pharmaceutical R&D spending slowed down from 6.4% in 2016 to a steady of 3% in 2019, the R&D spending of Chinese pharmaceutical companies kept growing, to reach a current high speed of 25-30%. One major engine comes from the Chinese government’s healthcare reform. The 2019 ‘centralized procurement’ policy has largely squeezed out the gross margin of the imitation pharmaceutical companies, pushing them to further accelerate innovation. WuXi AppTec (2359:HKSE), Pharmaron (300759:SZ), Tigermed (300347:SH) and Asychem (002821:SZ), commonly known as the ‘Big Four’ among Chinese listed CROs, are usually mentioned in comparison with each other. They are all contract research organizations, or pharmaceutical R&D service providers, in the study of small molecule drugs (chemical drugs). But they anchor at different stages of the pre-market process, exerting various resources and advantages to build up their moats and consume this expanding market. Investability rooted in the growing trend Value investors care for the business and industry. A fast-growing sector is more attractive than mature cash-cow markets for new entrant investors, since a growing company gives higher returns, including time value and growth. The current CRO industry in China is showing a dynamic vitality based on two core factors: It is a high probability event for pharmaceutical companies, as the marginal return on investment (ROI) in developing innovative drugs is decreasing, considering the increasing cost of advanced researchers and the difficulty in discovering new targets. In China’s pharmaceutical ecology, companies are accelerating their process of developing new drugs, as they foresee an ample business space for R&D outsourcing services – CROs/CDMOs. Several flagship CROs are emerging at this growth stage, and the whole segment is in a high competition status. According to Pharmacube, the four-firm concentration rate is around 30%, indicating a more focused tendency in the market. Besides, the Big Four CROs have shown a speedy growth in revenue during the last few years, with a robust drive visible in the tier-one players. Along with the pre-market process of chemical drugs, Tigermed focuses on clinical trials (Phase I to Phase IV) and Asychem on commercialization. Pharmaron is extending its touch into the Phase I clinical trial and the clinical manufacturing service. WuXi AppTec, together with its subsidiary CDMO STA Pharmaceutical, provides an end-to-end coverage, including the research of pre-clinical and clinical stages, manufacturing and commercialization. Revenue/business introductions In the case of CRO companies, they recognize revenue when ‘a performance obligation is satisfied’ – i.e. the R&D service is completed according to IFRS 15. Its revenue is recorded proportionally as costs are incurred. From the perspective of revenue in 2019,  WuXi AppTec outperformed the other three, with the highest income – of CNY 12.87 billion. As the only one-stop pre-market R&D outsourcing service provider, WuXi AppTec also takes a stronghold in the field of pre-clinical CRO and CDMO, at a revenue of CNY 6.47 billion and CNY 3.75 billion, compared to Pharmaron’s  CNY 2.38 billion and Asychem’s CNY 2.46. However, Tigermed shows a more robust capability in the clinical CRO area, with a  2019 revenue of CNY 2.8 billion – more than twice that of WuXi AppTec. The clinical stage of a new drug includes trials from Phase I to Phase IV, among which Phase IV is the trial phase during the initial commercialization. Gold in the clinical trials For every new Drug, four phases of clinical trials are needed; it will also be tested on over a thousand human samples to make it stand out from a candidate pool of around five.  This is the process wherein the most intellectual value is created. Tigermed makes revenue mainly from two principal businesses: clinical trial solutions and clinical-related services and laboratory services. The clinical trial solutions cover a wide range, from innovative drugs, generic drugs and medical devices to associated serves, such as medical writing translation, registration and pharmacovigilance – accounting for 43.8% of total gross margins. The other business track mainly serves the drug development process, including data management and statistical analysis, site management and patient recruitment, medical imaging and lab services. Even though this unit generates an even higher gross margin of 48.68%, it is the auxiliary element, supporting the primary clinical trial services. Power from R&D In an overview of the expense structure of Tigermed, the direct labor and clinical trial fees are recorded in the operating costs. The cost for the researchers increased by over 5% relative to the overall operating income. According to the IFRS, one noteworthy matter is that, in the CRO industry, R&D spending is recorded into operating costs based on the fulfillment of the contracts. Its R&D investment mainly covers the social insurance of R&D staff, software development, system usage, equipment depreciation, etc. Plus, this clinical research company does not capitalize on its R&D expenses – for the last three years, the capitalized R&D was zero. What increased along with the R&D spending through 2017 is the number of R&D staff members at Tigermed – from 378 researchers in 2017 to 468 in 2019. The R&D efficiency is another perspective to compare all these laboratory-heavy pharmaceutical companies. In those medicine companies, R&D efficiency is usually derived by dividing revenues with R&D expenses. The higher the ratio, the more income every penny of R&D investment earns. However, in the setting of the CRO industry, it is a different story. Since the most significant service provided by CROs is laboratory experiments, they recognize these R&D fees as their major cost related to their contract revenues. As for the R&D expenses shown on their financial reports, these figures reflect costs for those failed experiments. Thus, the lower this R&D efficiency ratio, the more efficiently these lab trials perform. WuXi AppTec has kept a relatively stable and high R&D efficiency, partly because it has the most extensive coverage all along the process before an innovative drug hits the market. It is expected to generate many synergies out of different medical pipelines and stages. In specific areas, Tigermed focuses on clinical trials with increased R&D efficiency over the last three years – an advancement in their laboratory capacity. As for the CMO Asychem,  its primary business includes medical devices research, manufacturing during the clinical stage and commercialization. According to AnXin securities, in the promising clinical CRO industry, Tigermed takes the largest share – 10.4% – of the domestic market while WuXi AppTec accounts for 2.6%. Along the lifecycle of industry, ‘big and complete’ players appear at a particular stage. In a pre-mature industry, smaller, perfectly formed companies with a specific focus will create more positive externality, benefiting the industry overall.

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Updated 24 hours ago · Tencent Tech

JD Health’s New Move on Hong Kong IPO

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Sep 18, 2020 10:58 am · VCbeat

Biotech IMAB’s In-Process New Drug Enters Clinical Trials

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Sep 15, 2020 01:58 pm · VCbeat

3D Printing Precision Medicine Industry Park Lands in Hunan

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Sep 14, 2020 06:22 pm · VCbeat

Genor Biopharma Passes the Hearing for Hong Kong IPO

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Sep 10, 2020 12:42 pm · VCbeat

WeMed Secures CNY 100 Mn in Series C+ from GL Ventures

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